Formulation and evaluation of mucoadhesive microspheres of ciprofloxacin shiv shankar hardenia1, ankit jain 1, ritesh patel, anu kaushal2 1. Bioadhesive microspheres as sustained release drug delivery system. Microspheres are made from polymeric, waxy or protective materials that is biodegradable synthetic polymers and modified natural products. International journal of pharmaceutics, 39 1987 189199. An approach to controlled release dosage form ahmed, maizbha uddin, mahmood, sharif, islam, mohammad safiqul on. Abstract based on the advantages of adhesion preparations and.
Process for preparation of microcapsules and microspheres 67. College of pharmacy, indore professional studies ips academy, knowledge village, agrabombay road, rajendra nagar, indore madhya pradesh, india. Thus the binding of mucin to cell surfaces, which is a result of. Results of preliminary trials indicate that volume of crosslinking agent, time for. The polymeric microspheres all have a bioadhesive force of at least 11 mncm 2 110 nm 2. Bioadhesive microspheres have advantages such as efficient absorption and enhanced bioavailability of drugs owing to a high surfacetovolume. Microspheres were prepared by the spray drying technique using eudragit rs100 and eudragit rl100. Mucoadhesivemicrospheres containing ketorolac for nasal mucoadhesivemicrospheres containing ketorolac for nasal administration biology essay. Mathiowitzs work on how to engineer multiwalled microspheres might solve some of these problems.
These kinds of microspheres exhibit a prolonged residence time at the site of application and causes intimate contact with the absorption. This article presents the spectrum of potential applications of bioadhesive microspheres in controlled drug delivery ranging from the small molecules, to peptides, and to the macromolecular. Bioadhesive properties hydrophilic polymers these are watersoluble polymers that swell when they come in contact with water and eventually undergo complete dissolution. Us6217908b1 bioadhesive microspheres and their use as. May 22, 2018 pdf formulation and evaluation of mucoadhesivemicrospheres of. Bioadhesive microspheres have advantages such as efficient absorption and enhanced bioavailability of drugs owing to a high surfacetovolume ratio, a much more intimate contact with the mucus layer, and specific targeting of drugs to the absorption site 912.
Gelatin microspheres, bioadhesive dosage forms, metronidazole, diclofenac, periodontal disease, sustained release. Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a crosslinking agent. Preparation of chitosan and thiolated chitosan microspheres. These kinds of microspheres exhibit a prolonged residence time at the site of application and causes intimate contact with the absorption site and produces better therapeutic action. The problems of frequent administration and variable low bioavailability. Hollow microspheres are used as additives to lower the density of a material. Techniques for the fabrication of bioadhesive microspheres, as well as a method for measuring bioadhesive forces between microspheres and selected segments of the gastrointestinal tract in vitro are also described. These microspheres provide advantages such as efficient absorption and increased bioavailability of drugs owing to high surfacetovolume ratio, a much more. Bioadhesive polymeric platforms for transmucosal drug. To achieve bioadhesion to the mucosal tissue, optimized microspheres were incorporated into bioadhesive tablets and were evaluated for in vitro drug release, in vitro and. Diclofenac sodium ds, antiinflammatory and metronidazole hydrochloride mh.
Chapter 1 introduction bioadhesive drug to delivery. Figure 2 a drop of liquid bioadhesive spreading over a softtissue surface. Bioadhesive microspheres as a potential nasal drug delivery system. Formulation and evaluation of mucoadhesive glipizide. Novel drug delivery systems ndds are the system where the man searches for new methods of entry of drugs in to the body in order to show its activity in the body.
Formulation and evaluation of mucoadhesivemicrospheres of ciprofloxacin shiv shankar hardenia1, ankit jain 1. Bioadhesive microspheres for bioavailability enhancement. Formulation and evaluation of mucoadhesivemicrospheres of ciprofloxacin shiv shankar hardenia1, ankit jain 1, ritesh patel. This bioadhesive mucin consists of highly hydrated, crosslinked, linear, flexible and random coil glycoprotein molecules with net negative charge. Tablets were prepared by incorporating drug loaded microspheres and using bioadhesive polymers hydroxypropylmethylcellulose, sodium carboxymethylcellulose and carbopol. Microspheres are various types like bioadhesive microspheres, magnetic microspheres, floating microspheres, radioactive. An international journal of pharmaceutical science on deepdyve, the largest online. College of pharmacy, indore professional studies ips. Us6217908b1 bioadhesive microspheres and their use as drug. Microspheres constitute an important part of these particulate drug delivery systems by virtue of their small size and efficient carrier capacity, but coupling of bioadhesive properties to these microspheres. If the inline pdf is not rendering correctly, you can download the pdf file here. Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane. The spheres were collected by decantation, and the product thus separated was washed repeatedly with water to remove excess calcium impurity deposited on the surface of microspheres and dried at 45c for 12 hours. Bioadhesive microspheres as sustained release drug delivery.
Bioadhesive microspheres as a controlled drug delivery system. Bioadhesive microspheres for ophthalmic administration of. A novel electrobalancebased method to study adhesive interactions between individual microspheres and intestinal mucosa. Microsphere adhesives open a world of possibilities. Acyclovir loaded microspheres 10 mg of chitosan or thiolated chitosan were digested in hcl 0. Systems coated with these polymers show high bioadhesiveness to the mucosa in dry state but the bioadhesive nature deteriorates as they start dissolving. Microspheres are the carrier linked drug delivery system in which. Novel drug delivery systems ndds are the system where the. Request pdf bioadhesive microspheres as a controlled drug delivery system the concept of controlled drug delivery has been traditionally. A more specific term than bioadhesion is mucoadhesion. Carbomer gel loaded with microspheres of diclofenac and metronidazole is a potential localized delivery system for the treatment inflammation and infection in periodontal pockets. Mucoadhesive microspheres for gastroretentive delivery of. An international journal of pharmaceutical science on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract gi.
Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal candidiasis. Bioadhesive microspheres can be tailored to adhere to any mucosal tissue including those found in eye, nasal cavity, urinary and gi tract, thus offering the possibilities of localized as well as systemic controlled release of drugs. Microspheres constitute an important part of these particulate drug delivery systems by virtue of their small size and efficient carrier capacity, but coupling of bioadhesive properties to these microspheres has additional advantages such as prolong residence time of the dosage form at the site of absorption and intimate contact of the dosage. Bioadhesive vaginal tablets containing spray dried. The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide. Polyurethene, ureaformaldehyde, pmma, polystyrene 10 15 20 ncy % 0. Most mucosal surfaces such as in the gut or nose are covered by a layer of mucus. Solid biodegradable microspheres incorporating a drug.
Mucoadhesive microspheres as a controlled drug delivery system. Formulation of bioadhesive carbomer gel incorporating drug. Microspheres are manufactured in both solid and hollow form. The mucoadhesivemicrospheres were evaluated by in vitro and in vivo methods for controlled release. Formulation and evaluation of mucoadhesive glipizide microspheres. Pdf formulation and in vitro and in vivo characterization of. Microspheres are the carrier linked drug delivery system in which particle size ranges from 1 m range in diameter having a core of drug and entirely outer layers of polymer as coating material. Although they have less compressive strength, plastic microspheres offer many of the same advantages as rigid glass microspheres and are among the lightest fillers available. Microspheres, in general, have the potential to be used for targeted and controlled release.
Formulation and evaluation of mucoadhesive microspheres of. The release of drug from both biodegradable as well as nonbiodegradable microspheres is influenced by structure or micromorphology of the carrier and the properties of the polymer itself. First, inclusion complex of rhcl was prepared with cyclodextrin cd and then the complex was formulated as bioadhesive microspheres, using different proportions of carbopol cp and hpmc. Formulation of bioadhesive carbomer gel incorporating drugloaded gelatin microspheres for periodontal therapy k karthikeyan1, r durgadevi1, k saravanan1, k. Microspheres formulations using chitosan and thiolated chitosan as polymers were prepared using the method described by wang et al. Biodegradable polymers prolongs the residence time when contact with mucous.
Microspheres for use in a novel electromagnetic bioadhesion. Bioadhesive microparticles for controlled drug delivery raman juneja b. To formulate carbomer gel to localize and target drug action in periodontal pockets. Microspheres as a promising mucoadhesive drug delivery system. Inclusion in cds is a convenient alternative to improve the stability and solubility of poorly water soluble drugs 10. Bioadhesive microspheres as sustained release drug. On the other side, nonspecific bioadhesive polymers bind to both i. Bharadia, vikram pandya and darshan modi department of pharmaceutics, b. Mucoadhesivemicrospheres mucoadhesivemicrospheres free download as pdf file. Adhesion of drug delivery device to the mucosal membrane such as buccal, ocular, rectal, nasal etc can be termed as bio adhesion. Bioadhesive microspheres as a controlled drug delivery. Avoid the destabilizing forces of highshear pumping, filtering, highspeed mixing and coating methods. Mucoadhesive microspheres phd thesis proposal best essay. Natural polymers such as starch are used with the concept that they are.
Review on bioadhesive microspheres world journal of. Bioadhesives are natural polymeric materials that act as adhesives. Bioadhesion is the course of action which explains the interaction between an adhesive polymer naturalsynthetic with a biological substrate. Bioadhesive microspheres can be tailored to adhere to any mucosal tissue including those found in eye, nasal cavity, urinary, colon and gastrointestinal tract, thus offering the possibilities of localized as well.
Bioadhesive microspheres include microparticles and microcapsules having a core of the drug of 1. Magnetic microspheres are supramolecular particles that are small. Microspheres as a promising mucoadhesive drug delivery. Natural polymers such as starch are used with the concept that they are biodegradable, biocompatible, and also bioadhesive in nature. Mucoadhesive microsphere exhibit a prolonged residence time at the site of application and. Sodium alginate, carbopol 934, carbopol 971, hpmc k 4 m. Read bioadhesive microspheres for ophthalmic administration of acyclovir, journal of pharmacy and pharmacology. Mucoadhesive agents are usually polymers containing hydrogen bonding groups that can be used in wet formulations or in dry powders for drug. Bioadhesive microparticles for controlled drug delivery.
Microspheres were characterized by sem, dsc, ftir, particle size analysis and evaluated for percentage yield, drug loading, encapsulation efficiency and in vitro drug release. Microspheres constitute an important part of novel drug delivery system ndds by virtue of their small size and efficient carrier capacity. Bioadhesive microspheres adhesion can be defined as sticking of drug to the membrane by using the sticking property of the water soluble polymers. Adhesion of a matter to this layer is hence called mucoadhesion. The purpose of the present investigation was to compare the characteristics of the bioadhesive microspheres of celecoxib prepared using different polymers. Polymeric microspheres ibiodegradable polymeric microspheres iisynthetic polymeric microspheres 1. Evaluation of microspheres micromeritic properties determination of angle of repose. She has developed a onestep process for preparing doublewalled polymer microspheres based on. Dec 31, 2012 the microspheres were incorporated into carbomer gel and evaluated for drug release. Characterization and evaluation of bioadhesion involving hard, bioerodible polymers and soft tissue. The detailed researches about of celladhesive microspheres and some newstyle bioadhesive microspheres are mentioned. The adhesive work done is a sum of the surface tensions of the two adherent phases, less the interfacial tensions apparent between both phases wake, 1982. Loading, entrapment and encapsulation efficiencies of ds in the microsphere were 23. Use of specific bioadhesive polymers results in targeting of sites or.
Hussain the vagina as a route for systemic drug delivery j. The cell surface membrane also possesses a net negative charge due to the presence of charged groups. Bioadhesive microspheres can be tailored to adhere to any mucosal tissue including those found in eye, nasal cavity, urinary and gi tract, thus offering the possibilities of localized as well as. The term is sometimes used more loosely to describe a glue formed synthetically from biological monomers such as sugars, or to mean. Apr 14, 2003 bioadhesive microspheres as a controlled drug delivery system.
Developments in the area of bioadhesive drug delivery systems. Microspheres are manufactured in both solid and hollow. Bioadhesive microspheres15, 16, 17 adhesion can be defined as sticking of drug to the membrane by using the sticking property of the water soluble polymers. The adhesive work done is a sum of the surface tensions of the two adherent phases, less the interfacial tensions. Pdf formulation and evaluation of mucoadhesivemicrospheres of. Meaningful clinical application of bioadhesive microspheres are also of current concerns and need more detailed researches. Carbopol 71g and methocel k15m microspheres were dispersed in 0. The release profile from the microspheres depends on the nature of the polymer used in the preparation as well as on the nature of the active drug.
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